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In some embodiments, the human antibody contains a CDR-H2 having at least 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence of the corresponding CDR-H2 region within a sequence encoded by a germline nucleotide human heavy chain V segment. In some embodiments, the human antibody contains a CDR-L2 having at least 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence of the corresponding CDR-L2 region within a sequence encoded by a germline nucleotide human light chain V segment. In some embodiments, the human antibody contains a CDR-L3 having at least 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence of the corresponding CDR-L3 region within a sequence encoded by a germline nucleotide human light chain V segment and J segment. In a further embodiment, a host cell comprising such nucleic acid is provided. In a further embodiment, one or more vectors (e.g., expression vectors) comprising such nucleic acid are provided. In some embodiments, the epitope includes an amino acid at a position corresponding to one or more of the positions of CD19 corresponding to the following amino acids at the following positions of the human CD19 sequence set forth in SEQ ID NO: 92: the histidine (H) at position 218, the alanine (A) at position 236, the methionine (M) at position 242, the glutamate (E) at position 243, the proline (P) at position 249, and/or the lysine (K) and/or serine (S) at positions 223 and 224. In some embodiments, an amino acid at one or more such a position is important or necessary for binding of the antibody to CD19.
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I truly love your site.. Excellent colors & theme. Did you make this website yourself?
Please reply back as I’m trying to create my very own site and would like to find out where you got this from or what the theme is called.
Appreciate it!
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In some embodiments, the human antibody contains a CDR-H2 having at least 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence of the corresponding CDR-H2 region within a sequence encoded by a germline nucleotide human heavy chain V segment. In some embodiments, the human antibody contains a CDR-L2 having at least 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence of the corresponding CDR-L2 region within a sequence encoded by a germline nucleotide human light chain V segment. In some embodiments, the human antibody contains a CDR-L3 having at least 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence of the corresponding CDR-L3 region within a sequence encoded by a germline nucleotide human light chain V segment and J segment. In a further embodiment, a host cell comprising such nucleic acid is provided. In a further embodiment, one or more vectors (e.g., expression vectors) comprising such nucleic acid are provided. In some embodiments, the epitope includes an amino acid at a position corresponding to one or more of the positions of CD19 corresponding to the following amino acids at the following positions of the human CD19 sequence set forth in SEQ ID NO: 92: the histidine (H) at position 218, the alanine (A) at position 236, the methionine (M) at position 242, the glutamate (E) at position 243, the proline (P) at position 249, and/or the lysine (K) and/or serine (S) at positions 223 and 224. In some embodiments, an amino acid at one or more such a position is important or necessary for binding of the antibody to CD19.
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I absolutely love your blog and find most of your post’s to be just what I’m looking for. Do you offer guest writers to write content for you personally? I wouldn’t mind producing a post or elaborating on a lot of the subjects you write with regards to here. Again, awesome web log!
Your style is unique in comparison to other people I have read stuff from. Thanks for posting when you have the opportunity, Guess I’ll just book mark this web site.
Everything is very open with a really clear clarification of the issues. It was definitely informative. Your site is extremely helpful. Many thanks for sharing!
This is very attention-grabbing, You are a very skilled blogger.
I have joined your rss feed and look ahead to seeking more of your magnificent post.
Additionally, I’ve shared your site in my social
networks
Its like you read my thoughts! You appear to grasp a lot about this, such as you wrote the ebook in it or something. I believe that you can do with a few percent to drive the message house a little bit, however instead of that, this is excellent blog. A great read. I’ll certainly be back.
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Spot on with this write-up, I seriously think this website needs much more attention. I’ll probably be back again to see more, thanks for the information!
Its like you learn my mind! You seem to understand a lot about this, like you wrote the e book in it or something. I think that you could do with a few p.c. to power the message house a bit, however instead of that, this is magnificent blog. An excellent read. I’ll certainly be back.
I love your blog.. very nice colors & theme. Did you create this website yourself or did you hire someone to do it for you? Plz answer back as I’m looking to create my own blog and would like to know where u got this from. appreciate it
Please let me know if you’re looking for a writer for your weblog. You have some really good posts and I feel I would be a good asset. If you ever want to take some of the load off, I’d love to write some material for your blog in exchange for a link back to mine. Please shoot me an email if interested. Kudos!
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Hey I am so happy I found your weblog, I really found you by accident, while I was browsing on Aol for something else, Anyways I am here now and would just like to say thank you for a marvelous post and a all round interesting blog (I also love the theme/design), I don’t have time to browse it all at the minute but I have book-marked it and also included your RSS feeds, so when I have time I will be back to read a great deal more, Please do keep up the excellent work.
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Did you develop this website yourself? Please reply back
as I’m looking to create my very own site and want to find out where you got this from or exactly what the theme is named.
Appreciate it!
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